Protein modifications in transcription elongation
نویسندگان
چکیده
منابع مشابه
A new role for histone tail modifications in transcription elongation.
RNA polymerase II (Pol II) faces a number of daunting tasks while transcribing genes. It must respond to a large array of transcription regulators, permitting distinct regulation of thousands of genes. It must coordinate its activities with RNA processing events and regulators of chromatin modifications and structure (Sims et al. 2004; Saunders et al. 2006). The C-terminal domain (CTD), a uniqu...
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Most transcription factors specify the subset of genes that will be actively transcribed in the cell by stimulating transcription initiation at these genes, but MYC has a fundamentally different role. MYC binds E-box sites in the promoters of active genes and stimulates recruitment of the elongation factor P-TEFb and thus transcription elongation. Consequently, rather than specifying the set of...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
سال: 2009
ISSN: 1874-9399
DOI: 10.1016/j.bbagrm.2008.07.008